Disney's 102 Dalmatians: Puppies to the Rescue is a 3D game based on the Disney film 102 Dalmatians. In this game, players must defeat the villain Cruella De Vil, her henchmen, and her ally Dr. Farzboom. Players take on the role of either Domino or Oddball, the Dalmatian puppies who are playing in the park looking for treasure. The two puppies did not know that their siblings have been captured by Cruella, who created toys that were programmed to capture all of the pets they see. They only find out that their siblings did not make it home when they got to the house. The puppies’ parents Dipstick and Dottie set out to find their puppies but are also captured along the way.
It is then up to the players, as Oddball or Domino, to rescue their family from Cruella’s evil clutches. To help players along, the game provides a friendly animal guide for every level who will tell players how to get through each mission. In return for the guide’s help, players have to do specific tasks for them. Along the way, players can collect stickers that will be placed in a virtual sticker book. In each level, players have to collect coins and rescue puppies. There are also mini-games that can be played and puzzles that must be solved.